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The studies within this thesis provide an evidence base for the continued development of an understanding of the assessment and management of overweight and obesity in older adults. A number of research priorities have also been highlighted. These include the need for long term randomised controlled clinical trials in older adults in order to: assess the efficacy and safety of multi component weight loss therapies (diet, physical activity and psychological therapy); determine the combination of physical activity and dietary therapy that will maximize loss of body fat while maintaining lean body mass in older adults for whom weight loss therapy is appropriate; and assess the effect of weight loss, diet and physical activity on clinical outcomes, particularly chronic disease end points and risk factors in older adults. is slim and trim cause for miscarriage My Dr said that I lost weight it was allright, and if I didnt gain any, it was allright, because I started out like 25 lbs (11.4 kgs) over weight as it was. But if you are worried about it, just ask your Dr.